selected publications
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academic article
- X-chromosome-wide association study for Alzheimer's disease.. Molecular psychiatry. 2024
- Association of Plasma YKL-40 With MRI, CSF, and Cognitive Markers of Brain Health and Dementia. Neurology. 2024
- Serum NfL and GFAP are associated with incident dementia and dementia mortality in older adults: The cardiovascular health study.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 19:5672-5680. 2023
- Association of Mitochondrial DNA Copy Number With Brain MRI Markers and Cognitive Function: A Meta-analysis of Community-Based Cohorts.. Neurology. 100:e1930-e1943. 2023
- Epigenetic and integrative cross-omics analyses of cerebral white matter hyperintensities on MRI.. Brain : a journal of neurology. 146:492-506. 2023
- Stroke genetics informs drug discovery and risk prediction across ancestries.. Nature. 611:115-123. 2022
- A population-based meta-analysis of circulating GFAP for cognition and dementia risk.. Annals of clinical and translational neurology. 9:1574-1585. 2022
- Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning.. Molecular psychiatry. 27:4419-4431. 2022
- Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate.. Brain : a journal of neurology. 145:1992-2007. 2022
- Meta-analysis of genome-wide association studies identifies ancestry-specific associations underlying circulating total tau levels.. Communications biology. 5:-. 2022
- New insights into the genetic etiology of Alzheimer's disease and related dementias.. Nature genetics. 54:412-436. 2022
- Correction: Association of low-frequency and rare coding variants with information processing speed.. Translational psychiatry. 12:-. 2022
- Associations of Pulmonary Function with MRI Brain Volumes: A Coordinated Multi-Study Analysis.. Journal of Alzheimer's disease : JAD. 90:1073-1083. 2022
- Large-scale sequencing studies expand the known genetic architecture of Alzheimer's disease.. Alzheimer's & dementia (Amsterdam, Netherlands). 13:-. 2021
- Association of Serum Neurofilament Light Chain Concentration and MRI Findings in Older Adults: The Cardiovascular Health Study.. Neurology. 98:e903-e911. 2021
- Genomic Studies Across the Lifespan Point to Early Mechanisms Determining Subcortical Volumes.. Biological psychiatry. Cognitive neuroscience and neuroimaging. 7:616-628. 2021
- Common variants in Alzheimer's disease and risk stratification by polygenic risk scores.. Nature communications. 12:-. 2021
- Cerebral small vessel disease genomics and its implications across the lifespan.. Nature communications. 11:-. 2020
- Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke.. Stroke. 51:2454-2463. 2020
- Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium.. Neurology. 95:e519-e531. 2020
- Plasma YKL40 as a biomarker for brain aging and injury in three community cohorts. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2020
- Association of CD14 with incident dementia and markers of brain aging and injury.. Neurology. 94:e254-e266. 2019
- Genetic architecture of subcortical brain structures in 38,851 individuals.. Nature genetics. 51:1624-1636. 2019
- Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype.. JAMA neurology. 76:1099-1108. 2019
- Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.. Nature genetics. 51:1423-1424. 2019
- A genome-wide association study identifies genetic loci associated with specific lobar brain volumes.. Communications biology. -. 2019
- The impact of APOE genotype on survival: Results of 38,537 participants from six population-based cohorts (E2-CHARGE).. PloS one. 14:-. 2019
- Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.. Nature communications. 10:-. 2019
- Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects.. Brain : a journal of neurology. 142:1009-1023. 2019
- Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.. Nature genetics. 51:414-430. 2019
- Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.. Neurology. 92:e486-e503. 2019
- GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.. Nature communications. 9:-. 2018
- Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke.. PloS one. 13:-. 2018
- Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.. American journal of human genetics. 103:691-706. 2018
- Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume.. Nature communications. 9:-. 2018
- Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation.. Molecular psychiatry. 25:1859-1875. 2018
- Exome Chip Analysis Identifies Low-Frequency and Rare Variants in MRPL38 for White Matter Hyperintensities on Brain Magnetic Resonance Imaging.. Stroke. 49:1812-1819. 2018
- Analysis of shared heritability in common disorders of the brain.. Science (New York, N.Y.). 360. 2018
- Genome-wide meta-analysis of SNP-by9-ACEI/ARB and SNP-by-thiazide diuretic and effect on serum potassium in cohorts of European and African ancestry.. The pharmacogenomics journal. 19:97-108. 2018
- Quality control and integration of genotypes from two calling pipelines for whole genome sequence data in the Alzheimer's disease sequencing project.. Genomics. 111:808-818. 2018
- Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.. Nature communications. 9:-. 2018
- Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.. Nature genetics. 50:524-537. 2018
- Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer's Disease Sequencing Project.. Dementia and geriatric cognitive disorders. 45:1-17. 2018
- Whole genome sequence analyses of brain imaging measures in the Framingham Study.. Neurology. 90:e188-e196. 2017
- Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium.. European journal of epidemiology. 32:931-938. 2017
- Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.. Nature genetics. 49:1373-1384. 2017
- Genetic variation at 16q24.2 is associated with small vessel stroke.. Annals of neurology. 81:383-394. 2017
- Novel genetic loci associated with hippocampal volume.. Nature communications. -. 2017
- Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease.. PLoS genetics. 12:-. 2016
- Novel genetic loci underlying human intracranial volume identified through genome-wide association.. Nature neuroscience. 19:1569-1582. 2016
- Evaluation of a Genetic Risk Score to Improve Risk Prediction for Alzheimer's Disease.. Journal of Alzheimer's disease : JAD. 53:921-32. 2016
- Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2.. Stroke. 47:307-16. 2016
- Rare Exome Sequence Variants in CLCN6 Reduce Blood Pressure Levels and Hypertension Risk.. Circulation. Cardiovascular genetics. 9:64-70. 2015
- White Matter Lesion Progression: Genome-Wide Search for Genetic Influences.. Stroke. 46:3048-57. 2015
- Shared genetic basis for migraine and ischemic stroke: A genome-wide analysis of common variants.. Neurology. 84:2132-45. 2015
- Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease.. Circulation. 131:2061-2069. 2015
- PLD3 variants in population studies.. Nature. 520:E2-3. 2015
- Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI.. Circulation. Cardiovascular genetics. 8:398-409. 2015
- Genetic overlap between diagnostic subtypes of ischemic stroke.. Stroke. 46:615-9. 2015
- Common genetic variants influence human subcortical brain structures.. Nature. 520:224-9. 2015
- Genes from a translational analysis support a multifactorial nature of white matter hyperintensities.. Stroke. 46:341-7. 2015
- Association of Alzheimer's disease GWAS loci with MRI markers of brain aging.. Neurobiology of aging. 36:1765.e7-1765.e16. 2015
- Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium.. Biological psychiatry. 77:749-63. 2014
- Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12.. Neurology. 83:678-85. 2014
- Associations of NINJ2 sequence variants with incident ischemic stroke in the Cohorts for Heart and Aging in Genomic Epidemiology (CHARGE) consortium.. PloS one. 9:-. 2014
- Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2.. Arteriosclerosis, thrombosis, and vascular biology. 34:1093-101. 2014
- Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies.. Stroke. 45:394-402. 2014
- Predicting stroke through genetic risk functions: the CHARGE Risk Score Project.. Stroke. 45:403-12. 2014
- Ischemic stroke is associated with the ABO locus: the EuroCLOT study.. Annals of neurology. 73:16-31. 2013
- Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.. The Lancet. Neurology. 11:951-62. 2012
- Common variants at 12q14 and 12q24 are associated with hippocampal volume.. Nature genetics. 44:545-51. 2012
- Identification of common variants associated with human hippocampal and intracranial volumes.. Nature genetics. 44:552-61. 2012
- No association of ALOX5AP polymorphisms with risk of MRI-defined brain infarcts.. Neurobiology of aging. 33:629.e1-3. 2011
- Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium.. Annals of neurology. 69:928-39. 2011
- Association of HSP70 and its co-chaperones with Alzheimer's disease.. Journal of Alzheimer's disease : JAD. 25:93-102. 2011
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