selected publications
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academic article
- N. Circulation. Heart failure. 17:-. 2024
- Epidemiologic Features of Recovery From SARS-CoV-2 Infection.. JAMA network open. 7:-. 2024
- The Gut Microbial Metabolite Trimethylamine N -oxide, Incident CKD, and Kidney Function Decline.. Journal of the American Society of Nephrology : JASN. 35:749-760. 2024
- Association of Plasma YKL-40 With MRI, CSF, and Cognitive Markers of Brain Health and Dementia. Neurology. 2024
- Plasma Ceramides and Sphingomyelins and Sudden Cardiac Death in the Cardiovascular Health Study.. JAMA network open. 6:-. 2023
- N. Journal of the American Heart Association. 12:-. 2023
- Serum NfL and GFAP are associated with incident dementia and dementia mortality in older adults: The cardiovascular health study.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 19:5672-5680. 2023
- Trimethylamine N-oxide is associated with long-term mortality risk: the multi-ethnic study of atherosclerosis.. European heart journal. 44:1608-1618. 2023
- Association of Mitochondrial DNA Copy Number With Brain MRI Markers and Cognitive Function: A Meta-analysis of Community-Based Cohorts.. Neurology. 100:e1930-e1943. 2023
- Epigenetic and integrative cross-omics analyses of cerebral white matter hyperintensities on MRI.. Brain : a journal of neurology. 146:492-506. 2023
- Stroke genetics informs drug discovery and risk prediction across ancestries.. Nature. 611:115-123. 2022
- A population-based meta-analysis of circulating GFAP for cognition and dementia risk.. Annals of clinical and translational neurology. 9:1574-1585. 2022
- Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning.. Molecular psychiatry. 27:4419-4431. 2022
- Plasma epoxyeicosatrienoic acids and diabetes-related cardiovascular disease: The cardiovascular health study.. EBioMedicine. -. 2022
- Dietary Meat, Trimethylamine N-Oxide-Related Metabolites, and Incident Cardiovascular Disease Among Older Adults: The Cardiovascular Health Study.. Arteriosclerosis, thrombosis, and vascular biology. 42:e273-e288. 2022
- Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate.. Brain : a journal of neurology. 145:1992-2007. 2022
- Collaborative Cohort of Cohorts for COVID-19 Research (C4R) Study: Study Design.. American journal of epidemiology. 191:1153-1173. 2022
- Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension.. Hypertension (Dallas, Tex. : 1979). 79:1656-1667. 2022
- Association of Trimethylamine N-Oxide and Metabolites With Mortality in Older Adults.. JAMA network open. 5:-. 2022
- New insights into the genetic etiology of Alzheimer's disease and related dementias.. Nature genetics. 54:412-436. 2022
- Correction: Association of low-frequency and rare coding variants with information processing speed.. Translational psychiatry. 12:-. 2022
- Associations of Pulmonary Function with MRI Brain Volumes: A Coordinated Multi-Study Analysis.. Journal of Alzheimer's disease : JAD. 90:1073-1083. 2022
- Association of Serum Neurofilament Light Chain Concentration and MRI Findings in Older Adults: The Cardiovascular Health Study.. Neurology. 98:e903-e911. 2021
- Circulating Ceramides and Sphingomyelins and Risk of Mortality: The Cardiovascular Health Study.. Clinical chemistry. 67:1650-1659. 2021
- Longitudinal Plasma Measures of Trimethylamine N-Oxide and Risk of Atherosclerotic Cardiovascular Disease Events in Community-Based Older Adults.. Journal of the American Heart Association. 10:-. 2021
- Association of Trimethylamine N-Oxide and Related Metabolites in Plasma and Incident Type 2 Diabetes: The Cardiovascular Health Study.. JAMA network open. 4:-. 2021
- Collaborative Cohort of Cohorts for COVID-19 Research (C4R) Study: Study Design.. medRxiv : the preprint server for health sciences. 2021
- Plasma epoxyeicosatrienoic acids and dihydroxyeicosatrieonic acids, insulin, glucose and risk of diabetes: The strong heart study.. EBioMedicine. -. 2021
- Cerebral small vessel disease genomics and its implications across the lifespan.. Nature communications. 11:-. 2020
- Multi-Ancestry Genome-wide Association Study Accounting for Gene-Psychosocial Factor Interactions Identifies Novel Loci for Blood Pressure Traits.. HGG advances. 2. 2020
- Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke.. Stroke. 51:2454-2463. 2020
- Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium.. Neurology. 95:e519-e531. 2020
- Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.. Molecular psychiatry. 26:2111-2125. 2020
- Plasma Ceramides and Sphingomyelins in Relation to Atrial Fibrillation Risk: The Cardiovascular Health Study.. Journal of the American Heart Association. 9:-. 2020
- Plasma YKL40 as a biomarker for brain aging and injury in three community cohorts. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2020
- Association of CD14 with incident dementia and markers of brain aging and injury.. Neurology. 94:e254-e266. 2019
- Genetic architecture of subcortical brain structures in 38,851 individuals.. Nature genetics. 51:1624-1636. 2019
- Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.. Nature genetics. 51:1423-1424. 2019
- Blood Leukocyte DNA Methylation Predicts Risk of Future Myocardial Infarction and Coronary Heart Disease.. Circulation. 140:645-657. 2019
- A genome-wide association study identifies genetic loci associated with specific lobar brain volumes.. Communications biology. -. 2019
- The impact of APOE genotype on survival: Results of 38,537 participants from six population-based cohorts (E2-CHARGE).. PloS one. 14:-. 2019
- Plasma Ceramides and Sphingomyelins in Relation to Heart Failure Risk.. Circulation. Heart failure. 12:-. 2019
- Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality.. Circulation. 139:2422-2436. 2019
- Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.. Nature communications. 10:-. 2019
- Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects.. Brain : a journal of neurology. 142:1009-1023. 2019
- Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association.. American journal of respiratory and critical care medicine. 199:631-642. 2019
- Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.. Nature genetics. 51:414-430. 2019
- Trajectories of Nonagenarian Health: Sex, Age, and Period Effects.. American journal of epidemiology. 188:382-388. 2019
- Genome-Wide Association Transethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels.. Circulation. 139:620-635. 2019
- Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.. Neurology. 92:e486-e503. 2019
- A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology.. Blood. 133:967-977. 2019
- Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.. Nature genetics. 51:51-62. 2018
- GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.. Nature communications. 9:-. 2018
- Circulating Very Long-Chain Saturated Fatty Acids and Heart Failure: The Cardiovascular Health Study.. Journal of the American Heart Association. 7:-. 2018
- Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.. American journal of human genetics. 103:691-706. 2018
- Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume.. Nature communications. 9:-. 2018
- Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation.. Molecular psychiatry. 25:1859-1875. 2018
- Exome Chip Analysis Identifies Low-Frequency and Rare Variants in MRPL38 for White Matter Hyperintensities on Brain Magnetic Resonance Imaging.. Stroke. 49:1812-1819. 2018
- Genome-wide meta-analysis of SNP-by9-ACEI/ARB and SNP-by-thiazide diuretic and effect on serum potassium in cohorts of European and African ancestry.. The pharmacogenomics journal. 19:97-108. 2018
- Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.. Nature communications. 9:-. 2018
- Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.. Nature genetics. 50:524-537. 2018
- Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent.. Molecular nutrition & food research. 62. 2017
- Concordance With Prevention Guidelines and Subsequent Cancer, Cardiovascular Disease, and Mortality: A Longitudinal Study of Older Adults.. American journal of epidemiology. 186:1168-1179. 2017
- Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium.. European journal of epidemiology. 32:931-938. 2017
- PCSK9. Circulation. Cardiovascular genetics. 10:-. 2017
- Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.. Nature genetics. 49:1373-1384. 2017
- Novel genetic loci associated with hippocampal volume.. Nature communications. -. 2017
- Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease.. PLoS genetics. 12:-. 2016
- Novel genetic loci underlying human intracranial volume identified through genome-wide association.. Nature neuroscience. 19:1569-1582. 2016
- Associations of Plasma Phospholipid SFAs with Total and Cause-Specific Mortality in Older Adults Differ According to SFA Chain Length.. The Journal of nutrition. 146:298-305. 2015
- Rare Exome Sequence Variants in CLCN6 Reduce Blood Pressure Levels and Hypertension Risk.. Circulation. Cardiovascular genetics. 9:64-70. 2015
- White Matter Lesion Progression: Genome-Wide Search for Genetic Influences.. Stroke. 46:3048-57. 2015
- Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians.. The American journal of clinical nutrition. 102:1266-78. 2015
- Directional dominance on stature and cognition in diverse human populations.. Nature. 523:459-462. 2015
- Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease.. Circulation. 131:2061-2069. 2015
- PLD3 variants in population studies.. Nature. 520:E2-3. 2015
- Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI.. Circulation. Cardiovascular genetics. 8:398-409. 2015
- Genetic overlap between diagnostic subtypes of ischemic stroke.. Stroke. 46:615-9. 2015
- Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction.. Nature. 518:102-6. 2014
- Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium.. Biological psychiatry. 77:749-63. 2014
- Genome-wide association study of L-arginine and dimethylarginines reveals novel metabolic pathway for symmetric dimethylarginine.. Circulation. Cardiovascular genetics. 7:864-72. 2014
- GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy.. The journals of gerontology. Series A, Biological sciences and medical sciences. 70:110-8. 2014
- Plasma phospholipid and dietary α-linolenic acid, mortality, CHD and stroke: the Cardiovascular Health Study.. The British journal of nutrition. 112:1206-13. 2014
- Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12.. Neurology. 83:678-85. 2014
- Associations of NINJ2 sequence variants with incident ischemic stroke in the Cohorts for Heart and Aging in Genomic Epidemiology (CHARGE) consortium.. PloS one. 9:-. 2014
- Loss-of-function mutations in APOC3, triglycerides, and coronary disease.. The New England journal of medicine. 371:22-31. 2014
- Glycated hemoglobin measurement and prediction of cardiovascular disease.. JAMA. 311:1225-33. 2014
- Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2.. Arteriosclerosis, thrombosis, and vascular biology. 34:1093-101. 2014
- Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies.. Stroke. 45:394-402. 2014
- Predicting stroke through genetic risk functions: the CHARGE Risk Score Project.. Stroke. 45:403-12. 2014
- Associations of plasma phospholipid and dietary alpha linolenic acid with incident atrial fibrillation in older adults: the Cardiovascular Health Study.. Journal of the American Heart Association. 2:-. 2013
- Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.. Circulation. Cardiovascular genetics. 6:171-83. 2013
- Ischemic stroke is associated with the ABO locus: the EuroCLOT study.. Annals of neurology. 73:16-31. 2013
- Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.. The Lancet. Neurology. 11:951-62. 2012
- A genome-wide association study of aging.. Neurobiology of aging. 32:2109.e15-28. 2011
- Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium.. Annals of neurology. 69:928-39. 2011