selected publications
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academic article
- Apolipoprotein E isoform does not influence trans-synaptic spread of tau pathology in a mouse model.. Brain and neuroscience advances. -. 2023
- Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice.. Nature communications. 12:-. 2021
- LRP1 is a master regulator of tau uptake and spread.. Nature. 580:381-385. 2020
- Experimental evidence for the age dependence of tau protein spread in the brain.. Science advances. 5:-. 2019
- Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo.. Nature Neuroscience. 22:57-64. 2018
- Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease.. Neuron. 99:925-940.e7. 2018
- in vitro. The Journal of biological chemistry. 293:13247-13256. 2018
- Reversible Cation-Selective Attachment and Self-Assembly of Human Tau on Supported Brain Lipid Membranes.. Nano letters. 18:3271-3281. 2018
- Tau protein liquid-liquid phase separation can initiate tau aggregation.. The EMBO journal. 37. 2018
- Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase.. Cell reports. 20:2304-2312. 2017
- Studying tau protein propagation and pathology in the mouse brain using adeno-associated viruses.. Methods in cell biology. 307-322. 2017
- Isoform- and cell type-specific structure of apolipoprotein E lipoparticles as revealed by a novel Forster resonance energy transfer assay.. The Journal of biological chemistry. 292:14720-14729. 2017
- Characterization of TauC3 antibody and demonstration of its potential to block tau propagation.. PloS one. 12:-. 2017
- Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro.. The American journal of pathology. 187:1399-1412. 2017
- Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease.. Synapse (New York, N.Y.). 71. 2017
- Human tau increases amyloid β plaque size but not amyloid β-mediated synapse loss in a novel mouse model of Alzheimer's disease.. The European journal of neuroscience. 44:3056-3066. 2016
- Formation, release, and internalization of stable tau oligomers in cells.. Journal of neurochemistry. 139:1163-1174. 2016
- Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients.. Annals of neurology. 80:355-67. 2016
- 3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice.. PloS one. 11:-. 2016
- Non-Fibrillar Oligomeric Amyloid-β within Synapses.. Journal of Alzheimer's disease : JAD. 53:787-800. 2016
- Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity.. The EMBO journal. 34:3028-41. 2015
- Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain.. Nature communications. -. 2015
- A Food and Drug Administration-approved asthma therapeutic agent impacts amyloid β in the brain in a transgenic model of Alzheimer disease.. The Journal of biological chemistry. 290:1966-78. 2014
- Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses.. Acta neuropathologica communications. -. 2014
- Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo.. Proceedings of the National Academy of Sciences of the United States of America. 111:510-4. 2013
- Tau-amyloid interactions in the rTgTauEC model of early Alzheimer's disease suggest amyloid-induced disruption of axonal projections and exacerbated axonal pathology.. The Journal of comparative neurology. 521:4236-48. 2013
- Propagation of tau pathology in Alzheimer's disease: identification of novel therapeutic targets.. Alzheimer's research & therapy. 5:-. 2013