selected publications
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academic article
- Association of Plasma YKL-40 With MRI, CSF, and Cognitive Markers of Brain Health and Dementia. Neurology. 2024
- A novel neuroimaging signature for ADRD risk stratification in the community.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 20:1881-1893. 2023
- Hypertension Trends and White Matter Brain Injury in the Offspring Framingham Heart Study Cohort.. Hypertension. 81:87-95. 2023
- Cerebral small vessel disease burden is associated with decreased abundance of gut Barnesiella intestinihominis bacterium in the Framingham Heart Study.. Scientific reports. 13:-. 2023
- Serum NfL and GFAP are associated with incident dementia and dementia mortality in older adults: The cardiovascular health study.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 19:5672-5680. 2023
- Sex differences in associations between APOE ε2 and longitudinal cognitive decline.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 19:4651-4661. 2023
- Association of Mitochondrial DNA Copy Number With Brain MRI Markers and Cognitive Function: A Meta-analysis of Community-Based Cohorts.. Neurology. 100:e1930-e1943. 2023
- The Nairobi Declaration-Reducing the burden of dementia in low- and middle-income countries (LMICs): Declaration of the 2022 Symposium on Dementia and Brain Aging in LMICs.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023
- Placental growth factor as a sensitive biomarker for vascular cognitive impairment.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 19:3519-3527. 2023
- Obesity impacts the expression of Alzheimer's disease-related genes: The Framingham Heart Study.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 19:3496-3505. 2023
- Epigenetic and integrative cross-omics analyses of cerebral white matter hyperintensities on MRI.. Brain : a journal of neurology. 146:492-506. 2023
- Secular Trends in Head Size and Cerebral Volumes In the Framingham Heart Study for Birth Years 1902-1985.. Research square. 2023
- Association of MRI Visible Perivascular Spaces and Neurofilament Light Chain: The Framingham Heart Study.. Journal of Alzheimer's disease : JAD. 95:1133-1145. 2023
- AD and non-AD mediators of the pathway between the APOE genotype and cognition.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 19:2508-2519. 2022
- MRI free water as a biomarker for cognitive performance: Validation in the MarkVCID consortium.. Alzheimer's & dementia (Amsterdam, Netherlands). 14:-. 2022
- Association of Red Blood Cell Omega-3 Fatty Acids With MRI Markers and Cognitive Function in Midlife: The Framingham Heart Study.. Neurology. 99:e2572-e2582. 2022
- Stroke genetics informs drug discovery and risk prediction across ancestries.. Nature. 611:115-123. 2022
- A population-based meta-analysis of circulating GFAP for cognition and dementia risk.. Annals of clinical and translational neurology. 9:1574-1585. 2022
- Plasma biomarkers predict cognitive trajectories in an ethnoracially and clinically diverse cohort: Mediation with hippocampal volume.. Alzheimer's & dementia (Amsterdam, Netherlands). 14:-. 2022
- Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning.. Molecular psychiatry. 27:4419-4431. 2022
- Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate.. Brain : a journal of neurology. 145:1992-2007. 2022
- Menopause Status Moderates Sex Differences in Tau Burden: A Framingham PET Study.. Annals of neurology. 92:11-22. 2022
- Meta-analysis of genome-wide association studies identifies ancestry-specific associations underlying circulating total tau levels.. Communications biology. 5:-. 2022
- New insights into the genetic etiology of Alzheimer's disease and related dementias.. Nature genetics. 54:412-436. 2022
- Instrumental validation of free water, peak-width of skeletonized mean diffusivity, and white matter hyperintensities: MarkVCID neuroimaging kits.. Alzheimer's & dementia (Amsterdam, Netherlands). 14:-. 2022
- Blood biomarkers for cognitive decline and clinical progression in a Mexican American cohort.. Alzheimer's & dementia (Amsterdam, Netherlands). 14:-. 2022
- Correction: Association of low-frequency and rare coding variants with information processing speed.. Translational psychiatry. 12:-. 2022
- Associations Between Brainstem Volume and Alzheimer's Disease Pathology in Middle-Aged Individuals of the Framingham Heart Study.. Journal of Alzheimer's disease : JAD. 86:1603-1609. 2022
- Associations of Pulmonary Function with MRI Brain Volumes: A Coordinated Multi-Study Analysis.. Journal of Alzheimer's disease : JAD. 90:1073-1083. 2022
- Insulin-Like Growth Factor, Inflammation, and MRI Markers of Alzheimer's Disease in Predominantly Middle-Aged Adults.. Journal of Alzheimer's disease : JAD. 88:311-322. 2022
- Association of Serum Neurofilament Light Chain Concentration and MRI Findings in Older Adults: The Cardiovascular Health Study.. Neurology. 98:e903-e911. 2021
- Multi-vendor and multisite evaluation of cerebrovascular reactivity mapping using hypercapnia challenge.. NeuroImage. -. 2021
- Genomic Studies Across the Lifespan Point to Early Mechanisms Determining Subcortical Volumes.. Biological psychiatry. Cognitive neuroscience and neuroimaging. 7:616-628. 2021
- Common variants in Alzheimer's disease and risk stratification by polygenic risk scores.. Nature communications. 12:-. 2021
- MarkVCID cerebral small vessel consortium: I. Enrollment, clinical, fluid protocols.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 17:704-715. 2021
- MarkVCID cerebral small vessel consortium: II. Neuroimaging protocols.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 17:716-725. 2021
- The cortical origin and initial spread of medial temporal tauopathy in Alzheimer's disease assessed with positron emission tomography.. Science translational medicine. 13. 2021
- Association of Midlife Depressive Symptoms with Regional Amyloid-β and Tau in the Framingham Heart Study.. Journal of Alzheimer's Disease. 82:249-260. 2021
- Cerebral small vessel disease genomics and its implications across the lifespan.. Nature communications. 11:-. 2020
- Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium.. Neurology. 95:e519-e531. 2020
- Corticosteroids and Regional Variations in Thickness of the Human Cerebral Cortex across the Lifespan.. Cerebral cortex (New York, N.Y. : 1991). 30:575-586. 2020
- Plasma YKL40 as a biomarker for brain aging and injury in three community cohorts. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2020
- Association of CD14 with incident dementia and markers of brain aging and injury.. Neurology. 94:e254-e266. 2019
- Mid-life and late-life vascular risk factor burden and neuropathology in old age.. Annals of clinical and translational neurology. 6:2403-2412. 2019
- Genetic architecture of subcortical brain structures in 38,851 individuals.. Nature genetics. 51:1624-1636. 2019
- A genome-wide association study identifies genetic loci associated with specific lobar brain volumes.. Communications biology. -. 2019
- Circulating IGFBP-2: a novel biomarker for incident dementia.. Annals of clinical and translational neurology. 6:1659-1670. 2019
- Plasma total-tau as a biomarker of stroke risk in the community.. Annals of neurology. 86:463-467. 2019
- Temporal Trends in Ischemic Stroke Incidence in Younger Adults in the Framingham Study.. Stroke. 50:1558-1560. 2019
- Assessment of Plasma Total Tau Level as a Predictive Biomarker for Dementia and Related Endophenotypes.. JAMA neurology. 76:598-606. 2019
- Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.. Nature communications. 10:-. 2019
- Full exploitation of high dimensionality in brain imaging: The JPND working group statement and findings.. Alzheimer's & dementia (Amsterdam, Netherlands). 286-290. 2019
- Circulating fibroblast growth factor 23 levels and incident dementia: The Framingham heart study.. PloS one. 14:-. 2019
- Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.. Neurology. 92:e486-e503. 2019
- Abstract TMP55: Abdominal Obesity Predicts Stroke Risk in the Framingham Study. Stroke. 2019
- APOE and the Association of Fatty Acids With the Risk of Stroke, Coronary Heart Disease, and Mortality.. Stroke. 49:2822-2829. 2018
- Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume.. Nature communications. 9:-. 2018
- Vascular risk at younger ages most strongly associates with current and future brain volume.. Neurology. 91:e1479-e1486. 2018
- Circulating Vascular Growth Factors and Magnetic Resonance Imaging Markers of Small Vessel Disease and Atrophy in Middle-Aged Adults.. Stroke. 49:2227-2229. 2018
- Cerebral tract integrity relates to white matter hyperintensities, cortex volume, and cognition.. Neurobiology of aging. 14-22. 2018
- Exome Chip Analysis Identifies Low-Frequency and Rare Variants in MRPL38 for White Matter Hyperintensities on Brain Magnetic Resonance Imaging.. Stroke. 49:1812-1819. 2018
- Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.. Nature communications. 9:-. 2018
- Author response: Sleep architecture and the risk of incident dementia in the community.. Neurology. 90:-. 2018
- Meta-analysis of epigenome-wide association studies of cognitive abilities.. Molecular psychiatry. 23:2133-2144. 2018
- Abstract 171: Endothelial Microparticle Levels and Silent Stroke in the Framingham Heart Study. Stroke. 2018
- Association of Nonalcoholic Fatty Liver Disease With Lower Brain Volume in Healthy Middle-aged Adults in the Framingham Study.. JAMA neurology. 75:97-104. 2018
- Whole genome sequence analyses of brain imaging measures in the Framingham Study.. Neurology. 90:e188-e196. 2017
- Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium.. European journal of epidemiology. 32:931-938. 2017
- Whole blood gene expression and white matter Hyperintensities.. Molecular neurodegeneration. 12:-. 2017
- Sleep architecture and the risk of incident dementia in the community.. Neurology. 89:1244-1250. 2017
- Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.. Nature genetics. 49:1373-1384. 2017
- Role of Improved Vascular Health in the Declining Incidence of Dementia.. Stroke. 48:2013-2020. 2017
- Aortic Stiffness, Increased White Matter Free Water, and Altered Microstructural Integrity: A Continuum of Injury.. Stroke. 48:1567-1573. 2017
- Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia: A Prospective Cohort Study.. Stroke. 48:1139-1146. 2017
- Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia.. Alzheimer's & dementia (New York, N. Y.). 3:229-237. 2017
- Sugary beverage intake and preclinical Alzheimer's disease in the community.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 13:955-964. 2017
- Novel genetic loci associated with hippocampal volume.. Nature communications. -. 2017
- Clinical and Environmental Correlates of Serum BDNF: A Descriptive Study with Plausible Implications for AD Research.. Current Alzheimer research. 14:722-730. 2017
- [O3–05–06]: REM SLEEP MECHANISMS PREDICT INCIDENT DEMENTIA IN THE FRAMINGHAM HEART STUDY. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2017
- Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease.. PLoS genetics. 12:-. 2016
- Novel genetic loci underlying human intracranial volume identified through genome-wide association.. Nature neuroscience. 19:1569-1582. 2016
- Aortic Stiffness and the Risk of Incident Mild Cognitive Impairment and Dementia.. Stroke. 47:2256-61. 2016
- Association of Ideal Cardiovascular Health With Vascular Brain Injury and Incident Dementia.. Stroke. 47:1201-6. 2016
- Effects of Arterial Stiffness on Brain Integrity in Young Adults From the Framingham Heart Study.. Stroke. 47:1030-6. 2016
- Incidence of Dementia over Three Decades in the Framingham Heart Study.. The New England journal of medicine. 374:523-32. 2016
- White Matter Lesion Progression: Genome-Wide Search for Genetic Influences.. Stroke. 46:3048-57. 2015
- Common genetic variants influence human subcortical brain structures.. Nature. 520:224-9. 2015
- O2‐05‐02: IMPACT OF AGE ON THE ASSOCIATION BETWEEN VASCULAR RISK FACTOR BURDEN AND BRAIN VOLUME. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2006
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