selected publications
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academic article
- Apolipoprotein E isoform does not influence trans-synaptic spread of tau pathology in a mouse model.. Brain and neuroscience advances. -. 2023
- Novel genetic variants in MAPT and alterations in tau phosphorylation in amyotrophic lateral sclerosis post-mortem motor cortex and cerebrospinal fluid.. Brain pathology (Zurich, Switzerland). 32:-. 2021
- Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis.. Molecular neurobiology. 59:683-702. 2021
- Opposing Roles of apolipoprotein E in aging and neurodegeneration.. Life science alliance. 2. 2019
- Beyond the neuron-cellular interactions early in Alzheimer disease pathogenesis.. Nature Reviews Neuroscience. 20:94-108. 2019
- Synaptic phosphorylated α-synuclein in dementia with Lewy bodies.. Brain : a journal of neurology. 140:3204-3214. 2017
- Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease.. Synapse (New York, N.Y.). 71. 2017
- Human tau increases amyloid β plaque size but not amyloid β-mediated synapse loss in a novel mouse model of Alzheimer's disease.. The European journal of neuroscience. 44:3056-3066. 2016
- Non-Fibrillar Oligomeric Amyloid-β within Synapses.. Journal of Alzheimer's disease : JAD. 53:787-800. 2016
- Amyloid-beta oligomerization is associated with the generation of a typical peptide fragment fingerprint.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 12:996-1013. 2016
- Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity.. The EMBO journal. 34:3028-41. 2015
- Carboxy terminus heat shock protein 70 interacting protein reduces tau-associated degenerative changes.. Journal of Alzheimer's disease : JAD. 44:937-47. 2015
- Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer's disease.. Acta neuropathologica communications. -. 2014
- Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses.. Acta neuropathologica communications. -. 2014
- The intersection of amyloid beta and tau at synapses in Alzheimer's disease.. Neuron. 82:756-71. 2014
- Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo.. Proceedings of the National Academy of Sciences of the United States of America. 111:510-4. 2013
- Tau-amyloid interactions in the rTgTauEC model of early Alzheimer's disease suggest amyloid-induced disruption of axonal projections and exacerbated axonal pathology.. The Journal of comparative neurology. 521:4236-48. 2013
- Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model.. Acta neuropathologica. 127:257-70. 2013
- Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain.. Science translational medicine. 5:-. 2013
- Propagation of tau pathology in Alzheimer's disease: identification of novel therapeutic targets.. Alzheimer's research & therapy. 5:-. 2013
- Reversal of neurofibrillary tangles and tau-associated phenotype in the rTgTauEC model of early Alzheimer's disease.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33:13300-11. 2013
- Studying synapses in human brain with array tomography and electron microscopy.. Nature protocols. 8:1366-80. 2013
- Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27:3239-48. 2013
- Soluble forms of tau are toxic in Alzheimer's disease.. Translational neuroscience. 3:223-233. 2012
- Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer's disease.. Nature neuroscience. 15:1422-9. 2012
- The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system.. The American journal of pathology. 181:1426-35. 2012
- Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β.. Brain : a journal of neurology. 135:2155-68. 2012
- Propagation of tau pathology in a model of early Alzheimer's disease.. Neuron. 73:685-97. 2012
- Nanoparticles enhance brain delivery of blood-brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging.. Proceedings of the National Academy of Sciences of the United States of America. 108:18837-42. 2011
- Alzheimer's disease: synapses gone cold.. Molecular neurodegeneration. 6:-. 2011
- Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain.. The American journal of pathology. 179:2071-82. 2011
- Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model.. Journal of neuropathology and experimental neurology. 70:588-95. 2011
- Are tangles as toxic as they look?. Journal of molecular neuroscience : MN. 45:438-44. 2011
- T cell mediated cerebral hemorrhages and microhemorrhages during passive Aβ immunization in APPPS1 transgenic mice.. Molecular neurodegeneration. -. 2011
- Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brain.. PloS one. 6:-. 2011
- Monitoring protein aggregation and toxicity in Alzheimer's disease mouse models using in vivo imaging.. Methods (San Diego, Calif.). 53:201-7. 2010
- Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice.. Neurobiology of disease. 41:650-4. 2010
- Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain.. Neuroscience letters. 487:260-3. 2010
- Caspase activation precedes and leads to tangles.. Nature. 464:1201-4. 2010
- A reporter of local dendritic translocation shows plaque- related loss of neural system function in APP-transgenic mice.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29:12636-40. 2009
- Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport.. Journal of neurochemistry. 111:417-27. 2009
- Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy.. Journal of neuropathology and experimental neurology. 68:757-61. 2009
- A single dose of passive immunotherapy has extended benefits on synapses and neurites in an Alzheimer's disease mouse model.. Brain research. 178-85. 2009
- Tau pathophysiology in neurodegeneration: a tangled issue.. Trends in neurosciences. 32:150-9. 2009
- Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease.. Neurobiology of disease. 33:213-20. 2008
- Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease.. Nature. 451:720-4. 2008
- In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28:862-7. 2008
- TAR-DNA binding protein 43 in Pick disease.. Journal of neuropathology and experimental neurology. 67:62-7. 2008
- Two postprocessing techniques for the elimination of background autofluorescence for fluorescence lifetime imaging microscopy.. Journal of biomedical optics. 13:-. 2008
- Impaired spine stability underlies plaque-related spine loss in an Alzheimer's disease mouse model.. The American journal of pathology. 171:1304-11. 2007
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