The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system.
Academic Article
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Overview
publication date
- August 4, 2012
has subject area
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Amyloid beta-Peptides
- Animals
- Biomarkers
- Centrifugation, Density Gradient
- Cerebral Cortex
- Female
- Humans
- Male
- Mice
- Middle Aged
- Phosphorylation
- Presynaptic Terminals
- Proteasome Endopeptidase Complex
- Protein Binding
- Protein Structure, Quaternary
- Protein Transport
- Synapses
- Ubiquitin
- Ubiquitination
- tau Proteins