selected publications
-
academic article
- Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer's disease.. Nature neuroscience. 27:2384-2400. 2024
- Interneuron diversity in the human dorsal striatum.. Nature Communications. 15:-. 2024
- Multifaceted roles of APOE in Alzheimer disease.. Nature Reviews Neurology. 20:457-474. 2024
- Characterization of monoamine oxidase-B (MAO-B) as a biomarker of reactive astrogliosis in Alzheimer's disease and related dementias.. Acta neuropathologica. 147:-. 2024
- Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer's disease reveals distinct sequential responses to Aβ and tau.. Acta neuropathologica. 147:-. 2024
- Alzheimer DataLENS: An Open Data Analytics Portal for Alzheimer's Disease Research.. Journal of Alzheimer's disease : JAD. 99:S397-S407. 2024
- Astrocyte tau deposition in progressive supranuclear palsy is associated with dysregulation of MAPT transcription. Acta Neuropathologica Communications. 2024
- Distinct transcriptomic responses to Aβ plaques, neurofibrillary tangles, and APOE in Alzheimer's disease.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 20:74-90. 2023
- Interneuron diversity in the human dorsal striatum.. Research square. 2023
- Endothelial Cells Are Heterogeneous in Different Brain Regions and Are Dramatically Altered in Alzheimer's Disease.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 43:4541-4557. 2023
- APOE. Neurology Genetics. 9:-. 2023
- Cyclic Multiplex Fluorescent Immunohistochemistry Protocol to Phenotype Glial Cells in Formalin-Fixed Paraffin-Embedded Human Brain Sections.. Methods in molecular biology (Clifton, N.J.). 283-305. 2023
- Development and Evaluation of a Natural Language Processing Annotation Tool to Facilitate Phenotyping of Cognitive Status in Electronic Health Records: Diagnostic Study.. Journal of medical Internet research. 24:-. 2022
- Plasma biomarkers for prognosis of cognitive decline in patients with mild cognitive impairment.. Brain communications. 4:-. 2022
- Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer's disease.. Journal of neuroinflammation. 19:-. 2022
- Systematic review of human post-mortem immunohistochemical studies and bioinformatics analyses unveil the complexity of astrocyte reaction in Alzheimer's disease.. Neuropathology and applied neurobiology. 48:-. 2021
- APOE. Nature Aging. 1:919-931. 2021
- Differential gene expression data from the human central nervous system across Alzheimer's disease, Lewy body diseases, and the amyotrophic lateral sclerosis and frontotemporal dementia spectrum.. Data in brief. -. 2021
- Author Correction: Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.. Nature medicine. 27:-. 2021
- APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches.. The Lancet. Neurology. 20:68-80. 2021
- Systematic review and meta-analysis of human transcriptomics reveals neuroinflammation, deficient energy metabolism, and proteostasis failure across neurodegeneration.. Neurobiology of disease. -. 2020
- Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration.. Journal of neuroinflammation. 17:-. 2020
- Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.. Nature medicine. 26:1256-1263. 2020
- Characterization of the 18 kDa translocator protein (TSPO) expression in post-mortem normal and Alzheimer's disease brains.. Brain pathology (Zurich, Switzerland). 30:151-164. 2019
- Thal Amyloid Stages Do Not Significantly Impact the Correlation Between Neuropathological Change and Cognition in the Alzheimer Disease Continuum.. Journal of neuropathology and experimental neurology. 75:516-26. 2016
- Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease.. The American journal of pathology. 186:375-84. 2015
- Alzheimer disease: Alzheimer dementia with sparse amyloid-AD mimic or variant?. Nature reviews. Neurology. 11:674-5. 2015
- Inhibition of amyloid-β plaque formation by α-synuclein.. Nature medicine. 21:802-7. 2015
- APOEε2 is associated with milder clinical and pathological Alzheimer disease.. Annals of neurology. 77:917-29. 2015
- Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer's disease.. Acta neuropathologica communications. -. 2014
- Mild to moderate Alzheimer dementia with insufficient neuropathological changes.. Annals of neurology. 75:597-601. 2014
- Studying synapses in human brain with array tomography and electron microscopy.. Nature protocols. 8:1366-80. 2013
- Differential relationships of reactive astrocytes and microglia to fibrillar amyloid deposits in Alzheimer disease.. Journal of neuropathology and experimental neurology. 72:462-71. 2013
- Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta.. Neuron. 78:631-43. 2013
- A phenotypic change but not proliferation underlies glial responses in Alzheimer disease.. The American journal of pathology. 182:2332-44. 2013
- The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system.. The American journal of pathology. 181:1426-35. 2012
- Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β.. Brain : a journal of neurology. 135:2155-68. 2012
- Neuropathological alterations in Alzheimer disease.. Cold Spring Harbor perspectives in medicine. 1:-. 2011
- Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology.. Brain : a journal of neurology. 133:1312-27. 2010
- Effects of simvastatin on cholesterol metabolism and Alzheimer disease biomarkers.. Alzheimer disease and associated disorders. 24:220-6. 2010