selected publications
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academic article
- A cross-disease resource of living human microglia identifies disease-enriched subsets and tool compounds recapitulating microglial states.. Nature neuroscience. 27:2521-2537. 2024
- β-Amyloid species production and tau phosphorylation in iPSC-neurons with reference to neuropathologically characterized matched donor brains.. Journal of neuropathology and experimental neurology. 83:772-782. 2024
- Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology.. eLife. 2024
- Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer's disease reveals distinct sequential responses to Aβ and tau.. Acta neuropathologica. 147:-. 2024
- Reply: Soluble oligomers or insoluble fibrils?. Acta Neuropathologica. 146:863-866. 2023
- Plasma biomarkers for diagnosis of Alzheimer's disease and prediction of cognitive decline in individuals with mild cognitive impairment.. Frontiers in neurology. -. 2023
- Altered localization of nucleoporin 98 in primary tauopathies.. Brain communications. 5:-. 2022
- Somatic genomic changes in single Alzheimer's disease neurons.. Nature. 604:714-722. 2022
- Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer's disease.. Journal of neuroinflammation. 19:-. 2022
- Genome-wide association study and functional validation implicates JADE1 in tauopathy.. Acta neuropathologica. 143:33-53. 2021
- Impact of Sterilization Methods on the Seeding Ability of Human Tau Proteopathic Seeds.. Journal of neuropathology and experimental neurology. 80:912-921. 2021
- C9ORF72. Science translational medicine. 13. 2021
- Cytoplasmic Mislocalization of RNA Polymerase II Subunit RPB1 in Alzheimer Disease Is Linked to Pathologic Tau.. Journal of neuropathology and experimental neurology. 80:530-540. 2021
- Kinetics of tau aggregation reveals patient-specific tau characteristics among Alzheimer's cases.. Brain communications. 3:-. 2021
- Continuous Monitoring of Tau-Induced Neurotoxicity in Patient-Derived iPSC-Neurons.. The Journal of Neuroscience. 41:4335-4348. 2021
- Author Correction: Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.. Nature medicine. 27:-. 2021
- Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns.. Journal of neuropathology and experimental neurology. 79:1141-1146. 2020
- Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease.. Frontiers in neurology. -. 2020
- Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.. Nature medicine. 26:1256-1263. 2020
- The Alzheimer Disease-Causing Presenilin-1 L435F Mutation Causes Increased Production of Soluble Aβ43 Species in Patient-Derived iPSC-Neurons, Closely Mimicking Matched Patient Brain Tissue.. Journal of neuropathology and experimental neurology. 79:592-604. 2020
- Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study.. Nature communications. 11:-. 2020
- Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.. Nature genetics. 51:1423-1424. 2019
- Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.. Nature genetics. 51:414-430. 2019
- Publisher Correction: Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease.. Nature neuroscience. 22:144-147. 2019
- Different tau species lead to heterogeneous tau pathology propagation and misfolding.. Acta neuropathologica communications. 6:-. 2018
- Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease.. Nature neuroscience. 21:1482-1492. 2018
- Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo.. Brain : a journal of neurology. 141:2194-2212. 2018
- Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain.. Frontiers in neuroscience. -. 2018
- Synaptic phosphorylated α-synuclein in dementia with Lewy bodies.. Brain : a journal of neurology. 140:3204-3214. 2017
- Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.. Nature genetics. 49:1373-1384. 2017
- Enhanced Tau Aggregation in the Presence of Amyloid β.. The American journal of pathology. 187:1601-1612. 2017
- Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro.. The American journal of pathology. 187:1399-1412. 2017
- Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients.. Annals of neurology. 80:355-67. 2016
- Amyloid-beta oligomerization is associated with the generation of a typical peptide fragment fingerprint.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 12:996-1013. 2016
- Thal Amyloid Stages Do Not Significantly Impact the Correlation Between Neuropathological Change and Cognition in the Alzheimer Disease Continuum.. Journal of neuropathology and experimental neurology. 75:516-26. 2016
- Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease.. The American journal of pathology. 186:375-84. 2015
- Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening.. Scientific reports. -. 2015
- Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain.. Nature communications. -. 2015
- Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue.. Annals of neurology. 78:787-800. 2015
- Diagnostic value of lobar microbleeds in individuals without intracerebral hemorrhage.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 11:1480-1488. 2015
- Rarity of the Alzheimer disease-protective APP A673T variant in the United States.. JAMA neurology. 72:209-16. 2015
- Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.. JAMA neurology. 71:1394-404. 2014
- Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer's disease.. Acta neuropathologica communications. -. 2014
- Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias.. PLoS genetics. 10:-. 2014
- A novel GRN mutation (GRN c.708+6_+9delTGAG) in frontotemporal lobar degeneration with TDP-43-positive inclusions: clinicopathologic report of 6 cases.. Journal of neuropathology and experimental neurology. 73:467-73. 2014
- Mild to moderate Alzheimer dementia with insufficient neuropathological changes.. Annals of neurology. 75:597-601. 2014
- Studying synapses in human brain with array tomography and electron microscopy.. Nature protocols. 8:1366-80. 2013
- Differential relationships of reactive astrocytes and microglia to fibrillar amyloid deposits in Alzheimer disease.. Journal of neuropathology and experimental neurology. 72:462-71. 2013
- A phenotypic change but not proliferation underlies glial responses in Alzheimer disease.. The American journal of pathology. 182:2332-44. 2013
- The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system.. The American journal of pathology. 181:1426-35. 2012
- Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β.. Brain : a journal of neurology. 135:2155-68. 2012
- Neuropathological alterations in Alzheimer disease.. Cold Spring Harbor perspectives in medicine. 1:-. 2011
- Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain.. The American journal of pathology. 179:2071-82. 2011
- Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology.. Brain : a journal of neurology. 133:1312-27. 2010
- Predicting the location of entorhinal cortex from MRI.. NeuroImage. 47:8-17. 2009
- Preservation of neuronal number despite age-related cortical brain atrophy in elderly subjects without Alzheimer disease.. Journal of neuropathology and experimental neurology. 67:1205-12. 2008
- Adult onset leukodystrophy with neuroaxonal spheroids: clinical, neuroimaging and neuropathologic observations.. Brain pathology (Zurich, Switzerland). 19:39-47. 2008
- TAR-DNA binding protein 43 in Pick disease.. Journal of neuropathology and experimental neurology. 67:62-7. 2008
- Increase in the relative expression of tau with four microtubule binding repeat regions in frontotemporal lobar degeneration and progressive supranuclear palsy brains.. Acta neuropathologica. 114:471-9. 2007
- Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy.. Brain : a journal of neurology. 130:2310-9. 2007
- Plasma Abeta levels do not reflect brain Abeta levels.. Journal of neuropathology and experimental neurology. 66:264-71. 2007
- No alteration in tau exon 10 alternative splicing in tangle-bearing neurons of the Alzheimer's disease brain.. Acta neuropathologica. 112:439-49. 2006
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document
- A cross-disease human microglial framework identifies disease-enriched subsets and tool compounds for microglial polarization 2022
- Elucidation of Amyloid-Beta’s Gambit in Oligomerization: Truncated Aβ fragments of residues Aβ1-23, Aβ1-24 and Aβ1-25 rapidly seed to form SDS-stable, LMW Aβ oligomers that impair synaptic plasticity 2022