selected publications
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academic article
- X-chromosome-wide association study for Alzheimer's disease.. Molecular psychiatry. 2024
- Differential regulation of brain microvessel transcriptome and brain metabolome by western and heart-healthy dietary patterns in Ossabaw pigs.. Scientific reports. 14:-. 2024
- Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer's disease.. Nature neuroscience. 27:2384-2400. 2024
- TYK2 regulates tau levels, phosphorylation and aggregation in a tauopathy mouse model.. Nature Neuroscience. 27:2417-2429. 2024
- Tau, synapse loss and gliosis progress in an Alzheimer's mouse model after amyloid-β immunotherapy.. Brain : a journal of neurology. 2024
- Arc mediates intercellular tau transmission via extracellular vesicles.. bioRxiv : the preprint server for biology. 2024
- A cross-disease resource of living human microglia identifies disease-enriched subsets and tool compounds recapitulating microglial states.. Nature neuroscience. 27:2521-2537. 2024
- Amyloid removal and the appearance of brain volume loss.. The Lancet. Neurology. 23:957-958. 2024
- Aqueous extractable nonfibrillar and sarkosyl extractable fibrillar Alzheimer's disease tau seeds have distinct properties.. Acta Neuropathologica Communications. 12:-. 2024
- Pathways to personalized medicine-Embracing heterogeneity for progress in clinical therapeutics research in Alzheimer's disease.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 20:7384-7394. 2024
- β-Amyloid species production and tau phosphorylation in iPSC-neurons with reference to neuropathologically characterized matched donor brains.. Journal of neuropathology and experimental neurology. 83:772-782. 2024
- Neurofibrillary tangle-bearing neurons have reduced risk of cell death in mice with Alzheimer's pathology.. Cell reports. 43:-. 2024
- Interneuron diversity in the human dorsal striatum.. Nature Communications. 15:-. 2024
- Multifaceted roles of APOE in Alzheimer disease.. Nature Reviews Neurology. 20:457-474. 2024
- Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology.. eLife. 2024
- Toxic effects of mutant huntingtin in axons are mediated by its proline-rich domain.. Brain : a journal of neurology. 147:2098-2113. 2024
- SORL1 is a receptor for tau that promotes tau seeding.. The Journal of biological chemistry. 300:-. 2024
- Characterization of monoamine oxidase-B (MAO-B) as a biomarker of reactive astrogliosis in Alzheimer's disease and related dementias.. Acta neuropathologica. 147:-. 2024
- Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer's disease reveals distinct sequential responses to Aβ and tau.. Acta neuropathologica. 147:-. 2024
- APOE2 gene therapy reduces amyloid deposition and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease.. Molecular therapy : the journal of the American Society of Gene Therapy. 32:1373-1386. 2024
- The structural line between prion and "prion-like": Insights from prion protein and tau.. Current opinion in neurobiology. -. 2024
- Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia.. Acta neuropathologica. 147:-. 2024
- Alzheimer proteopathic tau seeds are biochemically a forme fruste of mature paired helical filaments.. Brain : a journal of neurology. 147:637-648. 2024
- Brain Vasculature Accumulates Tau and Is Spatially Related to Tau Tangle Pathology in Alzheimer's Disease.. Acta neuropathologica. 147:-. 2024
- Lewy body dementia: Overcoming barriers and identifying solutions.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 20:2298-2308. 2024
- Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease.. Annals of Neurology. 95:625-634. 2024
- Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological hallmark of TDP-43-associated Alzheimer's disease.. Acta neuropathologica. 147:-. 2024
- Alzheimer DataLENS: An Open Data Analytics Portal for Alzheimer's Disease Research.. Journal of Alzheimer's disease : JAD. 99:S397-S407. 2024
- Astrocyte tau deposition in progressive supranuclear palsy is associated with dysregulation of MAPT transcription. Acta Neuropathologica Communications. 2024
- Precision Brain Morphometry Using Cluster Scanning.. medRxiv : the preprint server for health sciences. 2023
- Reconstitution of the Alzheimer’s Disease Tau Core Structure from Recombinant Tau297–391 Yields Variable Quaternary Structures as Seen by Negative Stain and Cryo-EM. Biochemistry. 63:194-201. 2023
- Health phenome of Parkinson's patients reveals prominent mood-sleep cluster.. Research square. 2023
- Reply: Soluble oligomers or insoluble fibrils?. Acta Neuropathologica. 146:863-866. 2023
- Potential impact of the COVID-19 pandemic on everyday preferences for persons with cognitive impairment.. International psychogeriatrics. 36:1256-1261. 2023
- Apolipoprotein E isoform does not influence trans-synaptic spread of tau pathology in a mouse model.. Brain and neuroscience advances. -. 2023
- Specific detection of tau seeding activity in Alzheimer's disease using rationally designed biosensor cells.. Molecular Neurodegeneration. 18:-. 2023
- Distinct transcriptomic responses to Aβ plaques, neurofibrillary tangles, and APOE in Alzheimer's disease.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 20:74-90. 2023
- VWA3A. Molecular therapy. Nucleic acids. 296-304. 2023
- Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau.. Acta Neuropathologica. 146:191-210. 2023
- Interneuron diversity in the human dorsal striatum.. Research square. 2023
- Endothelial Cells Are Heterogeneous in Different Brain Regions and Are Dramatically Altered in Alzheimer's Disease.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 43:4541-4557. 2023
- The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson's disease.. Acta Neuropathologica Communications. 11:-. 2023
- Size matters: the impact of nucleus size on results from spatial transcriptomics.. Journal of translational medicine. 21:-. 2023
- Spatial characterization of tangle-bearing neurons and ghost tangles in the human inferior temporal gyrus with three-dimensional imaging.. Brain communications. 5:-. 2023
- Plasma biomarkers for diagnosis of Alzheimer's disease and prediction of cognitive decline in individuals with mild cognitive impairment.. Frontiers in neurology. -. 2023
- Common mouse models of tauopathy reflect early but not late human disease.. Molecular neurodegeneration. 18:-. 2023
- APOE. Neurology Genetics. 9:-. 2023
- Tissue libraries enable rapid determination of conditions that preserve antibody labeling in cleared mouse and human tissue.. eLife. 2023
- Rate of tau propagation is a heritable disease trait in genetically diverse mouse strains.. iScience. 26:-. 2023
- Age-Dependent Increase in Tau Phosphorylation at Serine 396 in Huntington's Disease Prefrontal Cortex.. Journal of Huntington's disease. 12:267-281. 2023
- Cyclic Multiplex Fluorescent Immunohistochemistry Protocol to Phenotype Glial Cells in Formalin-Fixed Paraffin-Embedded Human Brain Sections.. Methods in molecular biology (Clifton, N.J.). 283-305. 2023
- Altered localization of nucleoporin 98 in primary tauopathies.. Brain communications. 5:-. 2022
- Designing a quality assurance process for quality control of nuclear magnetic resonance metabolomics studies of human blood.. NMR in biomedicine. 36:-. 2022
- Projection of Care Partners' Preferences in the Proxy Assessments of Everyday Preferences for Persons With Cognitive Impairment.. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 31:254-263. 2022
- Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia.. Nature communications. 13:-. 2022
- A correlation map of genome-wide DNA methylation patterns between paired human brain and buccal samples.. Clinical epigenetics. 14:-. 2022
- APOE4 derived from astrocytes leads to blood-brain barrier impairment.. Brain : a journal of neurology. 145:3582-3593. 2022
- Development and Evaluation of a Natural Language Processing Annotation Tool to Facilitate Phenotyping of Cognitive Status in Electronic Health Records: Diagnostic Study.. Journal of medical Internet research. 24:-. 2022
- Plasma biomarkers for prognosis of cognitive decline in patients with mild cognitive impairment.. Brain communications. 4:-. 2022
- Technical Performance Evaluation of Olink Proximity Extension Assay for Blood-Based Biomarker Discovery in Longitudinal Studies of Alzheimer's Disease.. Frontiers in neurology. -. 2022
- Mapping the Spatial Distribution of Fibrillar Polymorphs in Human Brain Tissue.. Frontiers in neuroscience. -. 2022
- Somatic genomic changes in single Alzheimer's disease neurons.. Nature. 604:714-722. 2022
- Tau propagation is dependent on the genetic background of mouse strains.. Brain communications. 4:-. 2022
- A Nuclear Magnetic Resonance Spectroscopy Method in Characterization of Blood Metabolomics for Alzheimer's Disease.. Metabolites. 12. 2022
- Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer's disease.. Journal of neuroinflammation. 19:-. 2022
- Novel genetic variants in MAPT and alterations in tau phosphorylation in amyotrophic lateral sclerosis post-mortem motor cortex and cerebrospinal fluid.. Brain pathology (Zurich, Switzerland). 32:-. 2021
- Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis.. Molecular neurobiology. 59:683-702. 2021
- Genome-wide association study and functional validation implicates JADE1 in tauopathy.. Acta neuropathologica. 143:33-53. 2021
- In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease.. Science advances. 7:-. 2021
- Impact of Sterilization Methods on the Seeding Ability of Human Tau Proteopathic Seeds.. Journal of neuropathology and experimental neurology. 80:912-921. 2021
- Longitudinal Changes in Neuropsychiatric Symptoms: Impact of Discrepancy in Everyday Preferences Between Persons With Cognitive Impairment and Their Care Partners.. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 30:619-623. 2021
- Pathogenic tau accelerates aging-associated activation of transposable elements in the mouse central nervous system.. Progress in Neurobiology. -. 2021
- Current directions in tau research: Highlights from Tau 2020.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 18:988-1007. 2021
- Longitudinal differences in everyday preferences: Comparisons between people with cognitive impairment and their care partners.. International journal of geriatric psychiatry. 37. 2021
- Systematic review of human post-mortem immunohistochemical studies and bioinformatics analyses unveil the complexity of astrocyte reaction in Alzheimer's disease.. Neuropathology and applied neurobiology. 48:-. 2021
- C9ORF72. Science translational medicine. 13. 2021
- An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein.. Cell reports. 35:-. 2021
- Cytoplasmic Mislocalization of RNA Polymerase II Subunit RPB1 in Alzheimer Disease Is Linked to Pathologic Tau.. Journal of neuropathology and experimental neurology. 80:530-540. 2021
- Kinetics of tau aggregation reveals patient-specific tau characteristics among Alzheimer's cases.. Brain communications. 3:-. 2021
- Systematic in silico analysis of clinically tested drugs for reducing amyloid-beta plaque accumulation in Alzheimer's disease.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 17:1487-1498. 2021
- Regulation of tau internalization, degradation, and seeding by LRP1 reveals multiple pathways for tau catabolism.. The Journal of biological chemistry. -. 2021
- Visit-to-Visit Blood Pressure Variability, Neuropathology, and Cognitive Decline.. Neurology. 96:e2812-e2823. 2021
- Synaptic proteins associated with cognitive performance and neuropathology in older humans revealed by multiplexed fractionated proteomics.. Neurobiology of aging. 99-114. 2021
- Continuous Monitoring of Tau-Induced Neurotoxicity in Patient-Derived iPSC-Neurons.. The Journal of Neuroscience. 41:4335-4348. 2021
- Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice.. Nature communications. 12:-. 2021
- APOE. Nature Aging. 1:919-931. 2021
- Quantitative Methods for the Detection of Tau Seeding Activity in Human Biofluids.. Frontiers in neuroscience. -. 2021
- Conformational fingerprinting of tau variants and strains by Raman spectroscopy.. RSC advances. 11:8899-8915. 2021
- Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy Model.. Annals of neurology. 89:952-966. 2021
- Machine learning identifies candidates for drug repurposing in Alzheimer's disease.. Nature Communications. 12:-. 2021
- Differential gene expression data from the human central nervous system across Alzheimer's disease, Lewy body diseases, and the amyotrophic lateral sclerosis and frontotemporal dementia spectrum.. Data in brief. -. 2021
- Author Correction: Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.. Nature medicine. 27:-. 2021
- Predictors of the importance of everyday preferences for older adults with cognitive impairment.. International psychogeriatrics. 34:287-294. 2021
- APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches.. The Lancet. Neurology. 20:68-80. 2021
- Alzheimer disease. Nature Reviews Disease Primers. 2021
- Conformational fingerprinting of tau variants and strains by Raman spectroscopy. RSC Advances. 2021
- Heterogeneity of Tau Deposition and Microvascular Involvement in MCI and AD.. Current Alzheimer research. 18:711-720. 2021
- Systematic review and meta-analysis of human transcriptomics reveals neuroinflammation, deficient energy metabolism, and proteostasis failure across neurodegeneration.. Neurobiology of disease. -. 2020
- A multifactorial model of pathology for age of onset heterogeneity in familial Alzheimer's disease.. Acta neuropathologica. 141:217-233. 2020
- Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease.. Cell. 183:1699-1713.e13. 2020
- Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns.. Journal of neuropathology and experimental neurology. 79:1141-1146. 2020
- Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds.. Acta Neuropathologica Communications. 8:-. 2020
- Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease.. Frontiers in neurology. -. 2020
- Tau reduction in aged mice does not impact Microangiopathy.. Acta neuropathologica communications. 8:-. 2020
- Synergy between amyloid-β and tau in Alzheimer's disease.. Nature Neuroscience. 23:1183-1193. 2020
- Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration.. Journal of neuroinflammation. 17:-. 2020
- Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.. Nature medicine. 26:1256-1263. 2020
- GBA. Neurology. 95:e685-e696. 2020
- The Alzheimer Disease-Causing Presenilin-1 L435F Mutation Causes Increased Production of Soluble Aβ43 Species in Patient-Derived iPSC-Neurons, Closely Mimicking Matched Patient Brain Tissue.. Journal of neuropathology and experimental neurology. 79:592-604. 2020
- Alternatives to amyloid for Alzheimer's disease therapies-a symposium report.. Annals of the New York Academy of Sciences. 1475:3-14. 2020
- LRP1 is a master regulator of tau uptake and spread.. Nature. 580:381-385. 2020
- PTEN activation contributes to neuronal and synaptic engulfment by microglia in tauopathy.. Acta neuropathologica. 140:7-24. 2020
- Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies.. Brain communications. 2:-. 2020
- Differences in Assessment of Everyday Preferences Between People With Cognitive Impairment and Their Care Partners: The Role of Neuropsychiatric Symptoms.. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 28:1070-1078. 2020
- Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study.. Nature communications. 11:-. 2020
- Associations of Lower Caffeine Intake and Plasma Urate Levels with Idiopathic Parkinson's Disease in the Harvard Biomarkers Study.. Journal of Parkinson's disease. 10:505-510. 2020
- Characterizing Clinical and Neuropathological Traits of APOE Haplotypes in African Americans and Europeans.. Journal of Alzheimer's disease : JAD. 78:467-477. 2020
- α-Synuclein strains target distinct brain regions and cell types.. Nature neuroscience. 23:21-31. 2019
- Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.. Nature genetics. 51:1423-1424. 2019
- Characterization of the 18 kDa translocator protein (TSPO) expression in post-mortem normal and Alzheimer's disease brains.. Brain pathology (Zurich, Switzerland). 30:151-164. 2019
- Experimental evidence for the age dependence of tau protein spread in the brain.. Science advances. 5:-. 2019
- The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques.. Cell reports. 27:1293-1306.e6. 2019
- Novel methods for integration and visualization of genomics and genetics data in Alzheimer's disease.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 15:788-798. 2019
- Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.. Nature genetics. 51:414-430. 2019
- Opposing Roles of apolipoprotein E in aging and neurodegeneration.. Life science alliance. 2. 2019
- Effects of Species-Specific Genetics on Alzheimer's Mouse Models.. Neuron. 101:351-352. 2019
- The NIH BRAIN Initiative: Integrating Neuroethics and Neuroscience.. Neuron. 101:394-398. 2019
- Beyond the neuron-cellular interactions early in Alzheimer disease pathogenesis.. Nature Reviews Neuroscience. 20:94-108. 2019
- Tau Prion-Like Propagation: State of the Art and Current Challenges.. Advances in experimental medicine and biology. 305-325. 2019
- Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo.. Nature Neuroscience. 22:57-64. 2018
- Neuroethics Guiding Principles for the NIH BRAIN Initiative.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 38:10586-10588. 2018
- Different tau species lead to heterogeneous tau pathology propagation and misfolding.. Acta neuropathologica communications. 6:-. 2018
- Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease.. Acta neuropathologica. 137:209-226. 2018
- Partial reduction of microglia does not affect tau pathology in aged mice.. Journal of neuroinflammation. 15:-. 2018
- Secretion and Uptake of α-Synuclein Via Extracellular Vesicles in Cultured Cells.. Cellular and molecular neurobiology. 38:1539-1550. 2018
- The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer's disease.. Journal of neuroinflammation. 15:-. 2018
- Neuronal calcineurin transcriptional targets parallel changes observed in Alzheimer disease brain.. Journal of neurochemistry. 147:24-39. 2018
- Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease.. Neuron. 99:925-940.e7. 2018
- β-Amyloid Induces Pathology-Related Patterns of Tau Hyperphosphorylation at Synaptic Terminals.. Journal of neuropathology and experimental neurology. 77:814-826. 2018
- Efficient Gene Transfer to the Central Nervous System by Single-Stranded Anc80L65.. Molecular therapy. Methods & clinical development. 197-209. 2018
- Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo.. Brain : a journal of neurology. 141:2194-2212. 2018
- in vitro. The Journal of biological chemistry. 293:13247-13256. 2018
- Analysis of shared heritability in common disorders of the brain.. Science (New York, N.Y.). 360. 2018
- Virus vector-mediated genetic modification of brain tumor stromal cells after intravenous delivery.. Journal of neuro-oncology. 139:293-305. 2018
- Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain.. Frontiers in neuroscience. -. 2018
- Reversible Cation-Selective Attachment and Self-Assembly of Human Tau on Supported Brain Lipid Membranes.. Nano letters. 18:3271-3281. 2018
- Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation.. The Journal of clinical investigation. 128:2144-2155. 2018
- CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease.. Molecular therapy. Nucleic acids. 429-440. 2018
- Tau protein liquid-liquid phase separation can initiate tau aggregation.. The EMBO journal. 37. 2018
- Mutant torsinA in the heterozygous DYT1 state compromises HSV propagation in infected neurons and fibroblasts.. Scientific reports. 8:-. 2018
- Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer's disease.. Proceedings of the National Academy of Sciences of the United States of America. 115:E1289-E1298. 2018
- Synaptic phosphorylated α-synuclein in dementia with Lewy bodies.. Brain : a journal of neurology. 140:3204-3214. 2017
- Poor Performance on a Preoperative Cognitive Screening Test Predicts Postoperative Complications in Older Orthopedic Surgical Patients.. Anesthesiology. 127:765-774. 2017
- Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase.. Cell reports. 20:2304-2312. 2017
- Studying tau protein propagation and pathology in the mouse brain using adeno-associated viruses.. Methods in cell biology. 307-322. 2017
- Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.. Nature genetics. 49:1373-1384. 2017
- Isoform- and cell type-specific structure of apolipoprotein E lipoparticles as revealed by a novel Forster resonance energy transfer assay.. The Journal of biological chemistry. 292:14720-14729. 2017
- Characterization of TauC3 antibody and demonstration of its potential to block tau propagation.. PloS one. 12:-. 2017
- Tau at the Crossroads between Neurotoxicity and Neuroprotection.. Neuron. 94:703-704. 2017
- Enhanced Tau Aggregation in the Presence of Amyloid β.. The American journal of pathology. 187:1601-1612. 2017
- Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro.. The American journal of pathology. 187:1399-1412. 2017
- Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease.. JAMA neurology. 74:427-436. 2017
- Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain.. Molecular neurodegeneration. 12:-. 2017
- Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease.. Synapse (New York, N.Y.). 71. 2017
- Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production.. Molecular neurodegeneration. 12:-. 2017
- Pathogenic PS1 phosphorylation at Ser367.. eLife. 2017
- Entorhinal Cortex: Antemortem Cortical Thickness and Postmortem Neurofibrillary Tangles and Amyloid Pathology. American Journal of Neuroradiology. 2017
- Trafficking of adeno-associated virus vectors across a model of the blood-brain barrier; a comparative study of transcytosis and transduction using primary human brain endothelial cells.. Journal of neurochemistry. 140:216-230. 2016
- Tailored transgene expression to specific cell types in the central nervous system after peripheral injection with AAV9.. Molecular therapy. Methods & clinical development. -. 2016
- Human tau increases amyloid β plaque size but not amyloid β-mediated synapse loss in a novel mouse model of Alzheimer's disease.. The European journal of neuroscience. 44:3056-3066. 2016
- Formation, release, and internalization of stable tau oligomers in cells.. Journal of neurochemistry. 139:1163-1174. 2016
- Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients.. Annals of neurology. 80:355-67. 2016
- Temporal T807 binding correlates with CSF tau and phospho-tau in normal elderly.. Neurology. 87:920-6. 2016
- 3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice.. PloS one. 11:-. 2016
- Preoperative Cognitive Stratification of Older Elective Surgical Patients: A Cross-Sectional Study.. Anesthesia and analgesia. 123:186-92. 2016
- Non-Fibrillar Oligomeric Amyloid-β within Synapses.. Journal of Alzheimer's disease : JAD. 53:787-800. 2016
- Amyloid-beta oligomerization is associated with the generation of a typical peptide fragment fingerprint.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 12:996-1013. 2016
- Thal Amyloid Stages Do Not Significantly Impact the Correlation Between Neuropathological Change and Cognition in the Alzheimer Disease Continuum.. Journal of neuropathology and experimental neurology. 75:516-26. 2016
- Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta.. BMC biology. -. 2016
- α-Synuclein in Extracellular Vesicles: Functional Implications and Diagnostic Opportunities.. Cellular and molecular neurobiology. 36:437-48. 2016
- The Feasibility of At-Home iPad Cognitive Testing For Use in Clinical Trials.. The journal of prevention of Alzheimer's disease. 3:8-12. 2016
- Tau positron emission tomographic imaging in aging and early Alzheimer disease.. Annals of neurology. 79:110-9. 2015
- Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease.. The American journal of pathology. 186:375-84. 2015
- Topological analyses in APP/PS1 mice reveal that astrocytes do not migrate to amyloid-β plaques.. Proceedings of the National Academy of Sciences of the United States of America. 112:15556-61. 2015
- Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening.. Scientific reports. -. 2015
- Alzheimer disease: Alzheimer dementia with sparse amyloid-AD mimic or variant?. Nature reviews. Neurology. 11:674-5. 2015
- Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity.. The EMBO journal. 34:3028-41. 2015
- Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain.. Nature communications. -. 2015
- Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue.. Annals of neurology. 78:787-800. 2015
- Massachusetts Alzheimer's Disease Research Center: progress and challenges.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 11:1241-5. 2015
- Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease.. Brain : a journal of neurology. 138:2659-71. 2015
- Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects.. Brain : a journal of neurology. 138:2701-15. 2015
- Cerebrospinal Fluid Particles in Alzheimer Disease and Parkinson Disease.. Journal of neuropathology and experimental neurology. 74:672-87. 2015
- Inhibition of amyloid-β plaque formation by α-synuclein.. Nature medicine. 21:802-7. 2015
- Oxidative stress and lipid peroxidation are upstream of amyloid pathology.. Neurobiology of disease. 109-19. 2015
- APOEε2 is associated with milder clinical and pathological Alzheimer disease.. Annals of neurology. 77:917-29. 2015
- Retinal blood flow in mild cognitive impairment and Alzheimer's disease.. Alzheimer's & dementia (Amsterdam, Netherlands). 1:144-51. 2015
- Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease.. Circulation. 131:2061-2069. 2015
- A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid.. Alzheimer's research & therapy. 7:-. 2015
- Rarity of the Alzheimer disease-protective APP A673T variant in the United States.. JAMA neurology. 72:209-16. 2015
- Carboxy terminus heat shock protein 70 interacting protein reduces tau-associated degenerative changes.. Journal of Alzheimer's disease : JAD. 44:937-47. 2015
- The Influence of Vascular Risk Factors and Stroke on Cognition in Late Life: Analysis of the NACC Cohort.. Alzheimer disease and associated disorders. 29:287-93. 2015
- A Food and Drug Administration-approved asthma therapeutic agent impacts amyloid β in the brain in a transgenic model of Alzheimer disease.. The Journal of biological chemistry. 290:1966-78. 2014
- Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.. JAMA neurology. 71:1394-404. 2014
- Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer's disease.. Acta neuropathologica communications. -. 2014
- Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias.. PLoS genetics. 10:-. 2014
- At the interface of sensory and motor dysfunctions and Alzheimer's disease.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 11:70-98. 2014
- Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses.. Acta neuropathologica communications. -. 2014
- Anti-ApoE antibody given after plaque onset decreases Aβ accumulation and improves brain function in a mouse model of Aβ amyloidosis.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34:7281-92. 2014
- The intersection of amyloid beta and tau at synapses in Alzheimer's disease.. Neuron. 82:756-71. 2014
- A novel GRN mutation (GRN c.708+6_+9delTGAG) in frontotemporal lobar degeneration with TDP-43-positive inclusions: clinicopathologic report of 6 cases.. Journal of neuropathology and experimental neurology. 73:467-73. 2014
- Mild to moderate Alzheimer dementia with insufficient neuropathological changes.. Annals of neurology. 75:597-601. 2014
- Direct visualization of CHIP-mediated degradation of alpha-synuclein in vivo: implications for PD therapeutics.. PloS one. 9:-. 2014
- RNA aptamer probes as optical imaging agents for the detection of amyloid plaques.. PloS one. 9:-. 2014
- Subjective cognitive concerns and neuropsychiatric predictors of progression to the early clinical stages of Alzheimer disease.. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 22:1642-51. 2014
- Measuring caspase activity in vivo.. Methods in enzymology. 251-69. 2014
- Regional cortical thinning and cerebrospinal biomarkers predict worsening daily functioning across the Alzheimer's disease spectrum.. Journal of Alzheimer's disease : JAD. 41:719-28. 2014
- Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo.. Proceedings of the National Academy of Sciences of the United States of America. 111:510-4. 2013
- Tau-amyloid interactions in the rTgTauEC model of early Alzheimer's disease suggest amyloid-induced disruption of axonal projections and exacerbated axonal pathology.. The Journal of comparative neurology. 521:4236-48. 2013
- Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model.. Acta neuropathologica. 127:257-70. 2013
- Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain.. Science translational medicine. 5:-. 2013
- Propagation of tau pathology in Alzheimer's disease: identification of novel therapeutic targets.. Alzheimer's research & therapy. 5:-. 2013
- The challenge of connecting the dots in the B.R.A.I.N.. Neuron. 80:270-4. 2013
- Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study.. Neurology. 81:1531-7. 2013
- Reversal of neurofibrillary tangles and tau-associated phenotype in the rTgTauEC model of early Alzheimer's disease.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33:13300-11. 2013
- Studying synapses in human brain with array tomography and electron microscopy.. Nature protocols. 8:1366-80. 2013
- Differential relationships of reactive astrocytes and microglia to fibrillar amyloid deposits in Alzheimer disease.. Journal of neuropathology and experimental neurology. 72:462-71. 2013
- Direct detection of alpha synuclein oligomers in vivo.. Acta neuropathologica communications. -. 2013
- Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27:3239-48. 2013
- Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta.. Neuron. 78:631-43. 2013
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